Poly-N-acetyllactosamine metabolic process

Across TCGA patient cohorts, RNA activity of the Poly-N-acetyllactosamine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COBLL1, ADCK1, and CAPN5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Poly-N-acetyllactosamine metabolic process activity versus COBLL1 in COAD (Pearson r = -0.03).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	COBLL1 →	+0.431	+0.095	<.001	<.001	3	5
LSCC	ADCK1 →	+0.203	+0.050	<.001	.003	3	5
OV	CAPN5 →	+0.567	+0.080	.001	<.001	3	5
OV	CDC42BPG →	+0.273	+0.058	.001	.001	3	5
LSCC	OTUB1 →	+0.153	+0.071	.003	<.001	3	5
OV	STMN1 →	-0.490	-0.055	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030309 vs COBLL1 — COAD

Explore this scatter interactively →