Poly-N-acetyllactosamine metabolic process

Across TCGA patient cohorts, RNA activity of the Poly-N-acetyllactosamine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAPDHP54, AK3, and ZNF517, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Poly-N-acetyllactosamine metabolic process activity versus GAPDHP54 in LUAD (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GAPDHP54 →	+0.598	+0.125	<.001	.001	3	4
UCEC	AK3 →	-0.335	-0.220	.007	.008	3	3
LUAD	ZNF517 →	+0.710	+0.133	.003	.004	3	3
HNSC	ATP13A4-AS1 →	+0.728	+0.091	.003	<.001	3	3
LSCC	ADNP →	+0.302	+0.077	.002	.006	3	2
GBM	GRIN2D →	+0.564	+0.957	.006	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030309 vs GAPDHP54 — LUAD

Explore this scatter interactively →