Poly-N-acetyllactosamine metabolic process

Across TCGA cell cohorts, RNA activity of the Poly-N-acetyllactosamine metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B3GNT2, B4GALT5, and B3GNT3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, B3GNT2 grouped by Poly-N-acetyllactosamine metabolic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	B3GNT2 →	-0.465	-1.640	<.001	<.001	3	10
CNS	B4GALT5 →	-0.257	-1.322	.007	.001	3	6
SKIN	B3GNT3 →	-0.271	-1.193	.003	.002	2	7
KIDNEY	AK3 →	+0.147	+1.129	.005	.004	3	5
STOMACH	KLK13 →	+0.171	+1.187	.009	.007	3	5
LUNG_SCLC	GAL3ST3 →	-0.284	-1.265	.001	.007	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

B3GNT2 by Poly-N-acetyllactosamine metabolic process activity — CNS

Explore this box plot interactively →