Poly-N-acetyllactosamine metabolic process

Across TCGA cell cohorts, RNA activity of the Poly-N-acetyllactosamine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MBNL3, RPL7A, and TAPBPL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MBNL3 grouped by Poly-N-acetyllactosamine metabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MBNL3 →	-1.430	-1.319	.004	.001	3	5
SOFT_TISSUE	RPL7A →	+0.868	+1.967	.003	<.001	3	5
CNS	TAPBPL →	-1.608	-1.191	<.001	.002	3	4
SOFT_TISSUE	FAM98B →	+0.588	+1.569	.003	<.001	3	4
LUNG_SCLC	KDM4B →	-0.923	-1.217	.001	.001	3	4
LUNG_SCLC	ANKS1A →	-0.840	-1.039	.006	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MBNL3 by Poly-N-acetyllactosamine metabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →