Poly-N-acetyllactosamine metabolic process

Across TCGA cell cohorts, RNA activity of the Poly-N-acetyllactosamine metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO8, CSNK1A1, and PRRX1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FBXO8 grouped by Poly-N-acetyllactosamine metabolic process-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	FBXO8 →	-0.325	-0.117	.008	.003	2	5
OVARY	CSNK1A1 →	+0.339	+1.005	.004	.007	3	4
PANCREAS	PRRX1 →	+0.164	+0.987	.008	.001	3	4
BLOOD_Leukemia	BCAR1 →	-0.182	-0.840	<.001	.005	3	3
URINARY_TRACT	ITGAV →	-0.946	-1.672	<.001	<.001	3	3
BREAST	KCNQ1 →	-0.119	-0.547	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FBXO8 by Poly-N-acetyllactosamine metabolic process activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →