Negative regulation of cell growth

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell growth pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRAGD, FAM161B, and UBXN6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RRAGD grouped by Negative regulation of cell growth-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RRAGD →	+1.439	+0.617	<.001	.005	3	4
BLOOD_Lymphoma	FAM161B →	-0.633	-0.279	.005	<.001	3	3
LUNG_NSCLC_LUAD	UBXN6 →	-0.568	-0.409	<.001	.009	2	4
BREAST	RALGPS1 →	+0.944	+0.128	.006	.005	2	3
OVARY	PAIP2B →	+0.976	+0.946	<.001	.003	3	2
OVARY	CARS2 →	-0.582	-0.617	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RRAGD by Negative regulation of cell growth activity — OVARY

Explore this box plot interactively →