Negative regulation of cell growth

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell growth pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THOC5, LMTK3, and CEP112, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell growth activity versus THOC5 in KIDNEY (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	THOC5 →	-0.613	-0.255	.008	.005	3	7
BREAST	LMTK3 →	+1.063	+0.189	.003	.009	3	7
PANCREAS	CEP112 →	-1.277	-0.259	.002	<.001	3	7
PANCREAS	HSH2D →	+2.281	+0.243	<.001	<.001	3	7
BREAST	LYPD3 →	+1.852	+0.191	.003	.005	3	7
OESOPHAGUS	SLC25A23 →	-1.287	-0.158	.001	.003	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030308 vs THOC5 — KIDNEY

Explore this scatter interactively →