Positive regulation of cell growth

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell growth pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GOLGA6D, R3HDM2P2, and HNRNPA1P37, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell growth activity versus GOLGA6D in OV (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GOLGA6D →	+0.152	+0.209	.009	.004	3	2
OV	R3HDM2P2 →	+0.188	+0.178	.002	.003	3	2
OV	HNRNPA1P37 →	+0.791	+0.251	.001	<.001	3	2
OV	RPL29P19 →	+0.985	+0.193	.002	<.001	3	2
OV	ANAPC1P6 →	+0.633	+0.227	.004	.001	3	2
BRCA	CHP1P1 →	+0.538	+0.337	.006	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030307 vs GOLGA6D — OV

Explore this scatter interactively →