Positive regulation of cell growth

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell growth pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF572, KLF12, and CDKL3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF572 grouped by Positive regulation of cell growth-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ZNF572 →	+0.941	+0.245	.002	.004	3	4
BONE	KLF12 →	+0.959	+0.276	.002	<.001	3	4
SOFT_TISSUE	CDKL3 →	+1.058	+0.180	.006	.003	3	4
PANCREAS	EPHX2 →	-1.142	-0.132	.001	<.001	3	4
STOMACH	SLC2A6 →	+2.240	+0.232	<.001	.002	3	4
LIVER	TMEM127 →	+0.982	+0.313	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF572 by Positive regulation of cell growth activity — SOFT_TISSUE

Explore this box plot interactively →