Positive regulation of cell growth

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell growth pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF704, PLEKHF2, and TMSB10, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell growth activity versus ZNF704 in OVARY (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ZNF704 →	-1.888	-0.206	<.001	<.001	3	6
OVARY	PLEKHF2 →	-1.041	-0.245	.003	<.001	2	7
SKIN	TMSB10 →	+1.168	+0.182	<.001	<.001	3	6
SKIN	LOXL2 →	+3.690	+0.204	<.001	<.001	3	5
OVARY	TSPAN5 →	+1.916	+0.216	.006	.003	3	5
OVARY	FOSL1 →	+2.942	+0.178	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030307 vs ZNF704 — OVARY

Explore this scatter interactively →