Intestinal cholesterol absorption

Across TCGA patient cohorts, RNA activity of the Intestinal cholesterol absorption pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TALDO1, MAOA, and PTDSS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intestinal cholesterol absorption activity versus TALDO1 in LUAD (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TALDO1 →	+0.482	+0.117	<.001	<.001	3	5
HNSC	MAOA →	+0.563	+0.112	.004	.003	3	5
LSCC	PTDSS1 →	+0.772	+0.158	<.001	<.001	3	5
LSCC	G6PD →	+0.617	+0.121	<.001	<.001	3	5
HNSC	ECH1 →	+0.468	+0.131	<.001	<.001	3	5
LSCC	AKR1C1 →	+1.529	+0.144	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030299 vs TALDO1 — LUAD

Explore this scatter interactively →