Intestinal cholesterol absorption

Across TCGA patient cohorts, RNA activity of the Intestinal cholesterol absorption pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIMA1, CENPF, and ANXA5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intestinal cholesterol absorption activity versus LIMA1 in HNSC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LIMA1 →	+0.807	+0.318	<.001	<.001	3	8
BRCA	CENPF →	-1.011	-0.223	<.001	<.001	3	6
OV	ANXA5 →	+0.811	+0.207	<.001	<.001	3	6
BRCA	CAVIN1 →	+0.900	+0.212	<.001	<.001	3	6
OV	SMIM3 →	+0.881	+0.222	<.001	<.001	3	6
OV	HEPH →	+1.113	+0.240	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030299 vs LIMA1 — HNSC

Explore this scatter interactively →