Intestinal cholesterol absorption

Across TCGA cell cohorts, RNA activity of the Intestinal cholesterol absorption pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSD3, GANC, and SPATA6L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PSD3 grouped by Intestinal cholesterol absorption-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PSD3 →	+1.590	+0.932	.001	.005	3	5
BLOOD_Lymphoma	GANC →	+1.120	+1.821	<.001	<.001	3	4
LUNG_SCLC	SPATA6L →	+1.226	+1.493	<.001	<.001	3	4
LUNG_NSCLC_LUSC	BEX5 →	+2.048	+1.451	.007	.001	3	4
CNS	ZKSCAN2 →	+0.379	+1.220	.007	<.001	3	4
LUNG_NSCLC_LUAD	DCAF12 →	+0.585	+0.633	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PSD3 by Intestinal cholesterol absorption activity — BLOOD_Leukemia

Explore this box plot interactively →