Bone mineralization

Across TCGA patient cohorts, RNA activity of the Bone mineralization pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDCA5, E2F1, and KIF15, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bone mineralization activity versus CDCA5 in HNSC (Pearson r = -0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CDCA5 →	-0.602	-0.292	.001	<.001	3	6
HNSC	E2F1 →	-0.537	-0.215	.003	.003	3	5
HNSC	KIF15 →	-0.664	-0.337	.004	<.001	3	5
GBM	CCNB1 →	-0.597	-0.160	.009	.004	3	5
OV	ZNHIT3 →	-0.352	-0.786	.007	.001	3	5
HNSC	CDCA3 →	-0.694	-0.352	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030282 vs CDCA5 — HNSC

Explore this scatter interactively →