Bone mineralization

Across TCGA cell cohorts, RNA activity of the Bone mineralization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRDM2, ODF2, and HEBP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRDM2 grouped by Bone mineralization-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PRDM2 →	-0.884	-1.294	<.001	.002	3	4
LUNG_NSCLC_LUAD	ODF2 →	-0.527	-0.798	.002	.003	3	4
LUNG_SCLC	HEBP1 →	+2.048	+1.339	.007	<.001	3	3
LARGE_INTESTINE	DPH7 →	-0.603	-1.084	.001	.001	3	3
LARGE_INTESTINE	ZNF417 →	-0.595	-0.824	.009	.001	3	3
LARGE_INTESTINE	CFAP44 →	-0.939	-0.744	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRDM2 by Bone mineralization activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →