Bone mineralization

Across TCGA cell cohorts, RNA activity of the Bone mineralization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNMT3A, CDK2AP1, and TIPIN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bone mineralization activity versus DNMT3A in BLOOD_Leukemia (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DNMT3A →	-1.706	-0.844	<.001	.003	3	4
KIDNEY	CDK2AP1 →	+0.862	+0.269	.002	.003	3	3
LUNG_NSCLC_LUSC	TIPIN →	+1.487	+0.406	<.001	.001	3	3
BREAST	GIT1 →	-0.766	-0.205	<.001	.003	3	3
BLOOD_Leukemia	CHD3 →	-1.154	-0.671	<.001	.009	3	3
UPPER_AERODIGESTIVE_TRACT	GLRX →	-1.416	-0.962	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030282 vs DNMT3A — BLOOD_Leukemia

Explore this scatter interactively →