Regulation of ossification

Across TCGA patient cohorts, RNA activity of the Regulation of ossification pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNMB1, NREP, and ZEB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ossification activity versus KCNMB1 in UCEC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KCNMB1 →	+0.714	+0.214	.006	.009	3	6
UCEC	NREP →	+0.461	+0.221	<.001	<.001	3	5
BRCA	ZEB1 →	+0.780	+0.361	.006	.006	3	5
COAD	PRKD1 →	+0.648	+0.805	.006	.001	3	5
BRCA	CC2D2B →	+0.190	+0.275	.001	.004	3	5
UCEC	ANTXR1 →	+0.626	+0.189	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030278 vs KCNMB1 — UCEC

Explore this scatter interactively →