Regulation of ossification

Across TCGA cell cohorts, RNA activity of the Regulation of ossification pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RXRA, ADORA1, and IL1R1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RXRA grouped by Regulation of ossification-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	RXRA →	-0.245	-0.943	.008	.008	2	6
BLOOD_Leukemia	ADORA1 →	-0.281	-1.032	.001	.001	3	5
OVARY	IL1R1 →	-0.289	-1.041	<.001	<.001	3	4
OVARY	ACVR2A →	-0.274	-1.147	.008	.002	3	4
OVARY	CPNE1 →	-0.201	-0.916	<.001	.008	3	4
BLOOD_Myeloma	BMP4 →	-0.238	-1.392	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RXRA by Regulation of ossification activity — BLOOD_Myeloma

Explore this box plot interactively →