Regulation of ossification

Across TCGA cell cohorts, RNA activity of the Regulation of ossification pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FANCA, FBXO22, and USB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FANCA grouped by Regulation of ossification-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	FANCA →	+1.368	+1.397	<.001	<.001	3	4
SOFT_TISSUE	FBXO22 →	-0.875	-1.276	.003	.001	3	4
KIDNEY	USB1 →	+1.058	+1.245	.002	<.001	3	3
KIDNEY	SF3B3 →	+1.238	+1.456	.001	<.001	3	3
STOMACH	PLXNA3 →	-1.198	-0.883	<.001	.009	3	3
LARGE_INTESTINE	MCIDAS →	-0.706	-0.532	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FANCA by Regulation of ossification activity — KIDNEY

Explore this box plot interactively →