Regulation of ossification

Across TCGA cell cohorts, RNA activity of the Regulation of ossification pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDCD1LG2, GPSM3, and MOB3C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ossification activity versus PDCD1LG2 in PANCREAS (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PDCD1LG2 →	+1.077	+0.463	.004	.008	3	4
LIVER	GPSM3 →	+1.841	+0.505	<.001	.003	3	4
SOFT_TISSUE	MOB3C →	+0.704	+0.521	.001	<.001	3	3
SOFT_TISSUE	PKIG →	+1.482	+0.482	<.001	.001	3	3
BREAST	PACSIN2 →	+1.021	+1.241	<.001	<.001	3	3
BONE	F3 →	+2.922	+0.754	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030278 vs PDCD1LG2 — PANCREAS

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