Chromosome condensation

Across TCGA cell cohorts, RNA activity of the Chromosome condensation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACBD7, ELAVL1, and HCFC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chromosome condensation activity versus ACBD7 in BLOOD_Leukemia (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ACBD7 →	+1.748	+0.220	<.001	<.001	3	6
KIDNEY	ELAVL1 →	+0.964	+0.324	.003	<.001	3	6
BLOOD_Leukemia	HCFC1 →	+0.651	+0.222	<.001	<.001	3	6
KIDNEY	ILF3 →	+0.781	+0.347	<.001	<.001	3	6
SOFT_TISSUE	USF2 →	+0.784	+0.223	.004	<.001	3	5
BLOOD_Leukemia	CBX5 →	+1.081	+0.243	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030261 vs ACBD7 — BLOOD_Leukemia

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