Lipid modification

Across TCGA patient cohorts, RNA activity of the Lipid modification pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NCL_S67, SH3BGRL2, and CRYL1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid modification activity versus NCL_S67 in LUAD (Pearson r = -0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NCL_S67 →	-0.869	-0.032	<.001	<.001	3	8
BRCA	SH3BGRL2 →	+0.736	+0.029	<.001	<.001	3	8
BRCA	CRYL1 →	+0.640	+0.030	<.001	<.001	3	8
LUAD	KIF23 →	-0.629	-0.027	<.001	<.001	3	8
BRCA	HYI →	+0.377	+0.019	.001	.002	3	8
LUAD	NAXD →	+0.296	+0.021	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030258 vs NCL_S67 — LUAD

Explore this scatter interactively →