Growth hormone secretion

Across TCGA patient cohorts, RNA activity of the Growth hormone secretion pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFFO1, ESR1, and MAF, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Growth hormone secretion activity versus IFFO1 in BRCA (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IFFO1 →	-0.653	-0.668	.002	.006	3	5
LUAD	ESR1 →	-0.788	-0.771	.001	.002	3	5
GBM	MAF →	-0.622	-1.106	<.001	<.001	3	4
GBM	COL11A1 →	-1.569	-0.674	<.001	<.001	3	4
LUAD	PLXNC1 →	-0.465	-0.699	<.001	.009	3	4
PDAC	ENTPD1 →	-0.282	-0.580	.008	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030252 vs IFFO1 — BRCA

Explore this scatter interactively →