Growth hormone secretion

Across TCGA patient cohorts, RNA activity of the Growth hormone secretion pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CDK16, SHANK2_S877, and MORC2_S743, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Growth hormone secretion activity versus CDK16 in OV (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CDK16 →	+0.378	+0.630	<.001	<.001	3	4
GBM	SHANK2_S877 →	+0.591	+0.875	.001	.002	3	3
GBM	MORC2_S743 →	+0.418	+0.732	<.001	.001	3	3
GBM	BUD13_S271 →	+0.689	+0.711	<.001	<.001	3	3
GBM	EIF5B_S182 →	+1.243	+0.904	<.001	.002	3	3
BRCA	CDK16_S138 →	+0.655	+0.694	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030252 vs CDK16 — OV

Explore this scatter interactively →