Autophagy of peroxisome

Across TCGA patient cohorts, RNA activity of the Autophagy of peroxisome pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SQSTM1, QPRT, and ARPC3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Autophagy of peroxisome activity versus SQSTM1 in LUAD (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SQSTM1 →	+0.883	+0.503	<.001	<.001	3	5
GBM	QPRT →	+0.665	+0.638	.002	.001	3	4
LSCC	ARPC3 →	+0.411	+0.621	<.001	<.001	3	4
PDAC	ROCK2 →	-0.246	-0.662	.008	.005	3	4
CCRCC	RALGAPA1 →	-0.322	-0.615	<.001	.003	3	4
PDAC	PRKD1 →	-0.348	-0.630	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030242 vs SQSTM1 — LUAD

Explore this scatter interactively →