Autophagy of peroxisome

Across TCGA cell cohorts, RNA activity of the Autophagy of peroxisome pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SQSTM1, SOBP, and MGAT4B, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Autophagy of peroxisome activity versus SQSTM1 in BLOOD_Lymphoma (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SQSTM1 →	+2.106	+1.003	<.001	.003	2	12
LIVER	SOBP →	-2.358	-1.931	.003	<.001	3	6
OVARY	MGAT4B →	+0.959	+1.006	.006	.005	2	7
LIVER	ARHGEF25 →	-2.060	-1.970	.003	<.001	3	5
PANCREAS	LRIG3 →	+1.536	+1.588	.006	<.001	3	5
PANCREAS	ATP1B1 →	+1.737	+1.126	.003	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030242 vs SQSTM1 — BLOOD_Lymphoma

Explore this scatter interactively →