Male sex determination

Across TCGA patient cohorts, RNA activity of the Male sex determination pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ACTR2, ARHGAP45_S578, and PLEKHO2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Male sex determination activity versus ACTR2 in BRCA (Pearson r = 0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ACTR2 →	-0.220	-0.062	<.001	.002	3	7
HNSC	ARHGAP45_S578 →	-0.656	-0.133	<.001	<.001	3	7
COAD	PLEKHO2 →	-0.488	-0.084	<.001	.001	2	8
COAD	SNX18 →	-0.298	-0.069	.005	.007	3	7
LSCC	BTK →	-0.372	-0.087	<.001	<.001	3	7
BRCA	ARPC3 →	-0.262	-0.058	<.001	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030238 vs ACTR2 — BRCA

Explore this scatter interactively →