Male sex determination

Across TCGA patient cohorts, RNA activity of the Male sex determination pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRC63, EIF1P2, and MFSD4A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Male sex determination activity versus LRRC63 in GBM (Pearson r = -0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LRRC63 →	-0.514	-0.653	.005	<.001	3	4
PDAC	EIF1P2 →	+0.150	+0.338	.002	.004	3	3
OV	MFSD4A →	+0.823	+0.753	.001	.003	3	2
OV	ZNF888 →	+0.501	+0.744	.009	.001	3	2
OV	GLDCP1 →	-0.922	-0.678	<.001	.004	3	2
OV	UBE2CP4 →	-0.462	-0.717	.009	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030238 vs LRRC63 — GBM

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