Male sex determination

Across TCGA cell cohorts, RNA activity of the Male sex determination pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTAFR, KRT24, and CYP2W1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTAFR grouped by Male sex determination-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PTAFR →	+0.173	+1.160	.008	.006	3	4
SOFT_TISSUE	KRT24 →	+0.470	+1.482	.001	.004	3	4
SOFT_TISSUE	CYP2W1 →	-0.170	-1.148	.002	<.001	3	4
SOFT_TISSUE	ZKSCAN4 →	-0.430	-1.695	<.001	<.001	3	3
LUNG_SCLC	PPP5C →	+0.182	+1.161	.002	<.001	3	3
LUNG_SCLC	NCR3LG1 →	-0.168	-1.199	.004	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTAFR by Male sex determination activity — LUNG_SCLC

Explore this box plot interactively →