Macrophage differentiation

Across TCGA patient cohorts, RNA activity of the Macrophage differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LNCAROD, FCGR2B, and RIN3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Macrophage differentiation activity versus LNCAROD in LUAD (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LNCAROD →	+0.491	+0.154	.003	.001	3	6
GBM	FCGR2B →	+0.735	+0.141	<.001	.002	3	6
BRCA	RIN3 →	+0.474	+0.147	.002	.001	3	5
UCEC	ARHGDIB →	+0.655	+0.193	.002	.003	3	5
BRCA	C1orf162 →	+0.599	+0.173	<.001	.001	3	5
HNSC	TMC8 →	+0.430	+0.093	.005	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030225 vs LNCAROD — LUAD

Explore this scatter interactively →