Macrophage differentiation

Across TCGA cell cohorts, RNA activity of the Macrophage differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PFKM, KIN, and KBTBD8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PFKM grouped by Macrophage differentiation-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PFKM →	+1.553	+1.739	.001	<.001	3	3
LUNG_NSCLC_LUSC	KIN →	+1.069	+1.372	.004	.004	3	3
PANCREAS	KBTBD8 →	+0.931	+1.403	<.001	.003	3	3
LUNG_SCLC	FOXA3 →	-1.248	-1.123	.006	<.001	3	3
LUNG_SCLC	CLPTM1L →	-1.221	-1.246	<.001	.002	3	3
BREAST	MON1A →	+0.523	+0.602	<.001	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PFKM by Macrophage differentiation activity — BLOOD_Lymphoma

Explore this box plot interactively →