Macrophage differentiation

Across TCGA cell cohorts, RNA activity of the Macrophage differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO5, ZNF286A, and SMC3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Macrophage differentiation activity versus FBXO5 in BREAST (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FBXO5 →	+0.829	+0.172	.004	.002	3	5
BLOOD_Leukemia	ZNF286A →	-1.156	-0.153	.007	.002	3	5
LIVER	SMC3 →	+1.047	+0.232	.008	.006	3	4
CNS	PELP1 →	+0.567	+0.198	.006	.009	3	4
KIDNEY	ASF1B →	+1.053	+0.220	.002	.004	3	4
LIVER	PARP2 →	+1.130	+0.264	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030225 vs FBXO5 — BREAST

Explore this scatter interactively →