Monocyte differentiation

Across TCGA patient cohorts, RNA activity of the Monocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPI1, LCP1, and INPP5D, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monocyte differentiation activity versus SPI1 in LSCC (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SPI1 →	+0.463	+0.063	<.001	<.001	3	8
GBM	LCP1 →	+0.700	+0.066	<.001	<.001	3	8
LSCC	INPP5D →	+0.447	+0.052	<.001	<.001	3	8
BRCA	RGS10 →	+0.346	+0.030	<.001	<.001	3	7
GBM	AIF1 →	+0.744	+0.067	<.001	<.001	3	7
GBM	LPXN →	+0.505	+0.057	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030224 vs SPI1 — LSCC

Explore this scatter interactively →