Monocyte differentiation

Across TCGA patient cohorts, RNA activity of the Monocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC41A3, ALDH4A1, and SYNGR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monocyte differentiation activity versus SLC41A3 in BRCA (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLC41A3 →	-0.457	-0.120	<.001	.002	3	5
CCRCC	ALDH4A1 →	-0.834	-0.184	<.001	<.001	3	4
GBM	SYNGR1 →	-0.762	-0.161	<.001	<.001	3	4
BRCA	DNAJB2 →	-0.519	-0.120	<.001	.002	2	5
GBM	AGAP1 →	-0.449	-0.142	<.001	<.001	3	4
GBM	CSF2RB →	+0.607	+0.126	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030224 vs SLC41A3 — BRCA

Explore this scatter interactively →