Neutrophil differentiation

Across TCGA patient cohorts, RNA activity of the Neutrophil differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADGRE2, LILRB3, and CXCL13, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutrophil differentiation activity versus ADGRE2 in GBM (Pearson r = 0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ADGRE2 →	+0.527	+0.331	<.001	.001	3	7
GBM	LILRB3 →	+0.803	+0.428	<.001	.005	3	7
BRCA	CXCL13 →	+1.811	+0.765	<.001	<.001	3	7
LSCC	IGKC →	+0.861	+0.269	.005	.006	3	7
CCRCC	LAX1 →	+0.991	+0.689	<.001	.001	3	6
UCEC	LILRB2 →	+0.771	+0.461	.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030223 vs ADGRE2 — GBM

Explore this scatter interactively →