Megakaryocyte differentiation

Across TCGA patient cohorts, RNA activity of the Megakaryocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLPX, GEM_S23, and POLDIP2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Megakaryocyte differentiation activity versus CLPX in HNSC (Pearson r = -0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CLPX →	-0.291	-0.065	<.001	<.001	3	10
LSCC	GEM_S23 →	+0.958	+0.055	<.001	<.001	3	10
LSCC	POLDIP2 →	-0.272	-0.048	<.001	<.001	3	10
HNSC	YME1L1 →	-0.312	-0.065	<.001	.001	3	9
OV	IL16 →	+0.434	+0.026	<.001	.001	3	9
UCEC	KCTD12 →	+0.554	+0.073	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030219 vs CLPX — HNSC

Explore this scatter interactively →