Megakaryocyte differentiation

Across TCGA patient cohorts, RNA activity of the Megakaryocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLX, TPM2, and TAGLN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Megakaryocyte differentiation activity versus HLX in CCRCC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HLX →	+0.531	+0.719	<.001	<.001	3	6
OV	TPM2 →	+0.996	+0.412	.004	.005	3	6
OV	TAGLN →	+1.134	+0.433	.004	.001	3	6
LSCC	C11orf96 →	+1.240	+0.240	<.001	<.001	3	6
LSCC	MMP19 →	+1.015	+0.212	<.001	.001	3	5
LSCC	TCIM →	+1.072	+0.200	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030219 vs HLX — CCRCC

Explore this scatter interactively →