Megakaryocyte differentiation

Across TCGA cell cohorts, RNA activity of the Megakaryocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COG2, PIGF, and ZNF761, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COG2 grouped by Megakaryocyte differentiation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	COG2 →	+0.674	+0.998	<.001	.004	3	4
LUNG_SCLC	PIGF →	+0.621	+0.919	.001	.004	3	4
LUNG_SCLC	ZNF761 →	+1.336	+1.368	.001	<.001	3	4
LUNG_SCLC	ZNF888 →	+1.384	+1.021	.004	.004	2	5
KIDNEY	HOMER2 →	-1.211	-1.094	.003	<.001	3	3
KIDNEY	PSMB8 →	+0.713	+0.990	.008	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COG2 by Megakaryocyte differentiation activity — SOFT_TISSUE

Explore this box plot interactively →