Keratinocyte differentiation

Across TCGA patient cohorts, RNA activity of the Keratinocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPL, ZNF185, and TNKS1BP1_S1666, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Keratinocyte differentiation activity versus PPL in HNSC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PPL →	+0.943	+0.093	<.001	<.001	3	9
UCEC	ZNF185 →	+0.722	+0.068	<.001	<.001	3	7
BRCA	TNKS1BP1_S1666 →	+0.620	+0.028	.003	.003	3	6
GBM	ANXA1 →	+0.722	+0.048	<.001	<.001	3	6
PDAC	TRIM29 →	+0.892	+0.026	<.001	<.001	3	6
PDAC	TRIM29_S21 →	+1.271	+0.033	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030216 vs PPL — HNSC

Explore this scatter interactively →