Keratinocyte differentiation

Across TCGA cell cohorts, RNA activity of the Keratinocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH1A3, STRBP, and GM2A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Keratinocyte differentiation activity versus ALDH1A3 in STOMACH (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ALDH1A3 →	+4.510	+0.246	<.001	.001	3	5
LARGE_INTESTINE	STRBP →	-1.097	-0.366	<.001	<.001	3	5
LUNG_NSCLC_LUSC	GM2A →	+1.796	+0.284	<.001	<.001	3	5
LARGE_INTESTINE	CLIP4 →	+1.558	+0.281	.005	<.001	3	5
LARGE_INTESTINE	PKD1L2 →	+0.579	+0.261	.003	<.001	3	5
LARGE_INTESTINE	SAMD9L →	+1.240	+0.249	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030216 vs ALDH1A3 — STOMACH

Explore this scatter interactively →