Hyaluronan catabolic process

Across TCGA patient cohorts, RNA activity of the Hyaluronan catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO32, CR1, and EFEMP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hyaluronan catabolic process activity versus FBXO32 in GBM (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FBXO32 →	+1.481	+0.377	<.001	<.001	3	7
GBM	CR1 →	+1.068	+0.356	<.001	<.001	3	5
BRCA	EFEMP1 →	+1.197	+0.192	.001	.002	3	5
GBM	VENTX →	+0.630	+0.267	<.001	<.001	3	5
GBM	FCGR2A →	+0.827	+0.267	<.001	<.001	3	5
GBM	VSIG4 →	+1.054	+0.230	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030214 vs FBXO32 — GBM

Explore this scatter interactively →