Hyaluronan catabolic process

Across TCGA patient cohorts, RNA activity of the Hyaluronan catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are F2, SHBG, and SERPING1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hyaluronan catabolic process activity versus F2 in CCRCC (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	F2 →	+0.490	+0.197	.003	<.001	3	5
GBM	SHBG →	+0.653	+0.227	<.001	<.001	2	6
GBM	SERPING1 →	+0.532	+0.337	<.001	<.001	3	5
GBM	LYVE1 →	+0.806	+0.297	<.001	<.001	3	5
BRCA	SLTM →	-0.312	-0.321	<.001	<.001	3	4
GBM	VSIG4 →	+0.707	+0.226	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030214 vs F2 — CCRCC

Explore this scatter interactively →