Hyaluronan catabolic process

Across TCGA cell cohorts, RNA activity of the Hyaluronan catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INPPL1, SELP, and TLR5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, INPPL1 grouped by Hyaluronan catabolic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	INPPL1 →	-0.206	-0.178	<.001	<.001	3	5
OVARY	SELP →	-0.147	-0.117	.005	.001	3	5
BREAST	TLR5 →	+0.158	+0.121	<.001	<.001	3	5
BLOOD_Leukemia	TBP →	-0.133	-0.093	.005	.004	3	4
BLOOD_Leukemia	NOCT →	-0.452	-0.170	<.001	<.001	3	4
LUNG_SCLC	MYDGF →	-0.257	-0.173	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

INPPL1 by Hyaluronan catabolic process activity — OESOPHAGUS

Explore this box plot interactively →