Hyaluronan catabolic process

Across TCGA cell cohorts, RNA activity of the Hyaluronan catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HEXB, POLR2D, and DDOST, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hyaluronan catabolic process activity versus HEXB in BONE (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	HEXB →	+2.452	+1.735	<.001	.003	3	7
LARGE_INTESTINE	POLR2D →	-0.334	-0.452	.004	.008	3	6
BLOOD_Leukemia	DDOST →	+0.770	+1.184	<.001	.001	3	6
BONE	LAMP2 →	+1.517	+1.702	<.001	<.001	3	6
BONE	CD44 →	+5.862	+1.659	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	ABHD12 →	+0.923	+0.180	.003	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030214 vs HEXB — BONE

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