Hyaluronan biosynthetic process

Across TCGA patient cohorts, RNA activity of the Hyaluronan biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDGFB, CEMIP, and IL1B, each associated with the pathway in up to 23 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hyaluronan biosynthetic process activity versus PDGFB in DLBC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	PDGFB →	+1.216	+0.085	<.001	<.001	2	23
DLBC	CEMIP →	+2.025	+0.075	<.001	<.001	2	23
DLBC	IL1B →	+1.976	+0.074	<.001	.001	2	23
UCS	HAS2 →	+1.750	+0.056	<.001	<.001	3	21
SCLC	ROBO4 →	+1.168	+0.155	<.001	<.001	3	20
SCLC	HBEGF →	+1.353	+0.148	<.001	<.001	2	20

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030213 vs PDGFB — DLBC

Explore this scatter interactively →