Hyaluronan biosynthetic process

Across TCGA patient cohorts, RNA activity of the Hyaluronan biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CPN1, A1BG, and ILK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hyaluronan biosynthetic process activity versus CPN1 in OV (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CPN1 →	+0.530	+0.059	.002	.003	3	6
GBM	A1BG →	+0.416	+0.066	<.001	<.001	3	6
OV	ILK →	+0.419	+0.072	<.001	<.001	3	6
OV	NCOA2_S493 →	-0.692	-0.059	.003	.001	3	6
OV	C4BPA →	+0.732	+0.059	.001	.002	3	5
OV	C4BPB →	+0.755	+0.068	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030213 vs CPN1 — OV

Explore this scatter interactively →