Hyaluronan biosynthetic process

Across TCGA patient cohorts, RNA activity of the Hyaluronan biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSPG5, TFF3, and TRAJ51, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hyaluronan biosynthetic process activity versus CSPG5 in OV (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CSPG5 →	-0.704	-0.342	<.001	.002	3	4
PDAC	TFF3 →	+1.692	+0.782	.003	.006	3	4
HNSC	TRAJ51 →	-1.235	-0.367	.003	.009	3	3
UCEC	PRSS3P1 →	-1.241	-0.389	.001	.003	3	3
CCRCC	RPL12P23 →	+0.077	+0.805	.004	.001	3	3
LUAD	PRB2 →	-0.418	-0.612	.001	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030213 vs CSPG5 — OV

Explore this scatter interactively →