Hyaluronan biosynthetic process

Across TCGA cell cohorts, RNA activity of the Hyaluronan biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MFSD2A, HACL1, and RPA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MFSD2A grouped by Hyaluronan biosynthetic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MFSD2A →	+3.632	+1.406	.002	<.001	3	4
SKIN	HACL1 →	+0.836	+1.445	<.001	<.001	3	4
SKIN	RPA1 →	+0.426	+0.770	.003	.006	3	4
BLOOD_Myeloma	ARL4A →	-2.075	-1.833	.002	<.001	3	3
BLOOD_Myeloma	USP7 →	-0.751	-1.361	.009	.009	3	3
LUNG_SCLC	TRIM9 →	+3.666	+1.471	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MFSD2A by Hyaluronan biosynthetic process activity — LUNG_SCLC

Explore this box plot interactively →