Hyaluronan biosynthetic process

Across TCGA cell cohorts, RNA activity of the Hyaluronan biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TFAP4, PCSK5, and PPP1R3C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TFAP4 grouped by Hyaluronan biosynthetic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TFAP4 →	+0.202	+0.603	.007	.008	3	5
CNS	PCSK5 →	+0.171	+0.459	<.001	.009	3	4
SOFT_TISSUE	PPP1R3C →	+0.218	+0.230	.005	.003	3	4
LARGE_INTESTINE	DDX17 →	-0.220	-0.672	.002	<.001	3	3
URINARY_TRACT	RMND5A →	-0.610	-0.445	.003	.004	3	3
BREAST	ERBB3 →	+0.558	+0.437	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TFAP4 by Hyaluronan biosynthetic process activity — LARGE_INTESTINE

Explore this box plot interactively →