Hyaluronan metabolic process

Across TCGA patient cohorts, RNA activity of the Hyaluronan metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPINA3, SMTN, and C8A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hyaluronan metabolic process activity versus SERPINA3 in GBM (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SERPINA3 →	+0.563	+0.049	<.001	<.001	3	7
HNSC	SMTN →	+0.369	+0.059	<.001	<.001	3	7
GBM	C8A →	+0.595	+0.061	<.001	<.001	3	7
GBM	CPN1 →	+0.682	+0.079	<.001	<.001	3	7
BRCA	F13B →	+0.714	+0.042	<.001	<.001	3	7
BRCA	FBL →	-0.405	-0.038	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030212 vs SERPINA3 — GBM

Explore this scatter interactively →